Mission
The mission of EmbRACE is to transform AF management by shifting the focus from reactive symptom control to proactive, mechanism-based prevention and therapy. This involves identifying the cellular, molecular, and electrophysiological mechanisms driving AtCM and AF, validating these in human tissue and advanced models, and translating findings into actionable clinical tools.

Goals
To achieve these goals, EmbRACE employs a multidisciplinary approach that spans basic, translational, and clinical research. The project integrates cutting-edge technologies such as single-nuclei RNA sequencing, computational modelling, AI-based rhythm pattern recognition, and patient-specific risk profiling. Clinically, it tests early intervention strategies including AF ablation and comprehensive cardiovascular risk management, with a strong emphasis on sex-specific responses and lifestyle impact.

A central clinical study within EmbRACE is the RACE X trial, designed to test the hypothesis that early rhythm control using ablation—before symptoms manifest—can prevent progression of AtCM and reduce cardiovascular complications. This trial focuses on patients with early paroxysmal AF and subclinical AtCM, comparing outcomes of early rhythm control versus standard rate control. It aims to generate the evidence needed to guide early intervention strategies and potentially shift clinical guidelines.

The ultimate goal is to develop and implement personalized care pathways that prevent AtCM progression, reduce AF burden, and improve patient outcomes. EmbRACE collaborates closely with cardiologists, general practitioners, and patient organizations to ensure real-world applicability and long-term impact. By creating an enduring network of researchers and clinicians, EmbRACE aims to redefine AF care across the patient journey—from early detection to sustained disease control.

EmbRACE also serves as a national platform to consolidate and elevate AF expertise in the Netherlands. It fosters collaboration between clinical and research groups and embeds their work within the broader international scientific community. Furthermore, EmbRACE is entrusted with stimulating and coordinating future AF-related grant applications to sustain innovation and leadership in this field.